| Title: | Nghiên cứu bào chế viên nén Acid Nicotinic giải phóng kéo dài 24 giờ |
| Other Titles: | 2017 |
| Authors: | Phạm Thị Minh Huệ, Bach Van Nguyen, Sonekeo Phommasone |
| Issue Date: | 2017 |
| Abstract: | Niacin
(nicotinic acid) is a highly water-soluble vitamin, which has been used
asa lipid-lowering agent. Sustained release (SR) niacin tablet was
developed in oder to maintain a constant drug concentration for a
specific period of time with minimum side effects. In this study, the
once daily extended release matrix tablets of niacin using a hydrophilic
polymer of HPMC K100M as matrix excipientwere prepared by wet
granulation method. The results of the dissolution study indicate that
the release of the drug was found to be dependent on the proportions of
HPMC used in the tablets. The dissolution profile of the optimal
formula was similar to that of the predict and attained the requirements
of USP 37. The dug incorporated in the matrix released by diffusionand
fitted the first order kinetic. |
| URI: | http://repository.vnu.edu.vn/handle/VNU_123/59635 |
| Appears in Collections: | Medical and Pharmaceutical Sciences |
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